MACDONALD, LYNN L,GURER, CAGAN C,MEAGHER, KAROLINA, A. KA,STEVENS, SEAN S,MURPHY, ANDREW, J. AJ,‧麥克唐納,‧古雷爾,‧梅格爾,‧史蒂文斯,‧莫菲
申请号：
HK15103518.0
公开号：
HK1202771A
申请日:
2015.04.10
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.
