There is provided a computerized method for estimating a dual-energy X-ray absorptiometry (DEXA) score from CT imaging data, comprising: receiving imaging data of a computed tomography (CT) scan of a body of a patient containing at least a bone portion； segmenting the bone portion from the imaging data； computing at least one grade based on pixel associated values from the bone portion； and correlating the at least one grade with at least one score representing a relation to bone density values in a population obtained based on a DEXA scan； wherein the grade is computed from a calculation of sub-grades performed for each one or a set of pixels having at least one of a common medial-lateral axial coordinate and a common cranial-caudal axial coordinate along a dorsal-ventral axis of a volume representation of the imaging data.
