Featured are methods and systems for reslicing-based nonrigid registration of multiparametric and modality images or objects. In such registration methods, global motion is modeled by multiple affine transforms (rigid), while local motion and slices matching is estimated using non-uniform radial reslicing of RTV to search for best match between reference volume slices and resampled target volume (RTV), orthogonally re-sliced to higher spatial resolution compared to the spatial resolution of the reference volume. The reference and target volumes can be in any plane and the method presented in this invention transfers them to target plane which can be any of axial, coronal, or sagittal and there is no need for the original and target scanning planes to be the same.
