AM ENDE, CHRISTOPHER WILLIAM,HUMPHREY, JOHN MICHAEL,JOHNSON, DOUGLAS SCOTT,KAUFFMAN, GREGORY WAYNE,PETTERSSON, MARTIN YOUNGJIN,RANKIC, DANICA ANTONIA,STEPAN, ANTONIA FRIEDERIKE,VERHOEST, PATRICK ROBER
申请号：
PH12016501864
公开号：
PH12016501864A1
申请日:
2016.09.22
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein X, R1, R2a, R2b, R4a, R4b, R5a, R5b, R6, R7, y and z are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. These compounds are ?-secretase modulators, useful for the treatment of neurodegenerative and/ or neurological disorders such as Alzheimer's disease and Down's syndrome.
