AKTOUDIANAKIS, Evangelos,CHIN, GREGORY,MACKMAN, Richard L.,METOBO, Samuel E.,MISH, Michael R.,PYUN, Hyung-jung,ZABLOCKI, Jeff
申请号：
PE2017001488
公开号：
PE20180031A1
申请日:
2016.03.02
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
The invention relates to aminopyridan derivatives from preparation (IVA), wherein R1 is h； R2 is h, methyl, F and Cl； R3 is h and methyl； residue-c (R13) (R14) (R12) is E-C (propilo) (CH3) (CH2OH)； C (butilo) (CH3) (CH2OH) or C (pentilo) (CH3) (CH2OH) (CH2OH). These compounds are modulators of toll type receivers, such as tlr-8 receivers. Also mentioned are pharmacology composersReferida a derivados de amino-pirido-pirimidina de formula (IVa), donde R1 es H； R2 es H, metilo, F y Cl； R3 es H y metilo； el residuo -C(R13)(R14)(R12) es -C(propilo)(CH3)(CH2OH), -C(butilo)(CH3)(CH2OH) o -C(pentilo)(CH3)(CH2OH). Dichos compuestos son moduladores del receptor de tipo toll como por ejemplo los receptores TLR-8. Tambien esta referida a composiciones farmaceuticas
