INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIP0 1 PCT Ilium omit Oil Oil mum ono mom oimIE (10) International Publication Number WO 2018/129559 Al (51) International Patent Classification: CO7K 16/28 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/013029 (22) International Filing Date: 09 January 2018 (09.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/444,336 09 January 2017 (09.01.2017) US 62/477,423 27 March 2017 (27.03.2017) US 62/491,220 27 April 2017 (27.04.2017) US 62/556,386 09 September 2017 (09.09.2017) US (71) Applicant: TESARO, INC. [US/US]； 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). (72) Inventors: JENKINS, David； c/o Tesaro, Inc., 1000 Win- ter Street North, Suite 3300, Waltham, MA 02451 (US). LAKEN, Haley； c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). IM, Ellie； c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). DIAZ, Allene； c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). LU, Sharon； c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). (74) Agent: ESPINO, Christine, G. et al.； Proskauer Rose LLP, One International Place, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN,
