ВАЙТМЭН Кэтлин Р. (US),О'ЛИРИ Джеймс Дж. (US),ЛАТЗ Роберт Джон (US),ОЛИРИ Джеймс Дж. (US)
申请号：
RU2012131663/15
公开号：
RU2012131663A
申请日:
2011.01.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition comprising an antibody or fragment thereof that specifically binds CD56, wherein said antibody or fragment thereof is coupled to a cytotoxic compound, wherein the above pharmaceutical composition also contains taxane compounds and platinum compounds, wherein the above pharmaceutical composition provides a synergistic effect in the treatment of cancer ovaries. 2. The pharmaceutical composition according to claim 1, characterized in that said cytotoxic compound is an antimitotic agent. The pharmaceutical composition according to claim 2, characterized in that said antimitotic agent is maytansinoid. The pharmaceutical composition according to claim 3, characterized in that said maytansinoid is DM1.5. The pharmaceutical composition according to claim 1, wherein the taxane compound is selected from the group consisting of: (a) paclitaxel； (b) docetaxel； and (c) a combination of (a) and (b) .6. The pharmaceutical composition according to claim 1, characterized in that said platinum compound is selected from the group consisting of: (a) carboplatin compound； (b) cisplatin compound； (c) oxaliplatin compound； (d) iroplatin compound； (e) ormaplatin compound ； and (e) tetraplatin compounds； (g) any combination of two or more (a) - (e). 7. A pharmaceutical composition according to any one of claims 1 to 6, characterized in that the antibody or fragment thereof is a humanized antibody or fragment thereof. A pharmaceutical composition according to any one of claims 1 to 6, characterized in that the antibody is huN901 or a fragment thereof. The pharmaceutical composition according to any one of claims 1 to 6, characterized in that the antibody associated with the cytotoxic compound1. Фармацевтическая композиция, включающая антитело или его фрагмент, который специфично связывает CD56, при этом указанное антитело или его фрагмент связаны с цитотоксическим соединением, где вышеуказанная фармацевтическая композиция также содержит соединения таксана и со
