The invention relates to a device for plasma treatment of living tissue, with a plasma source for generating an atmospheric plasma jet, with a support device for a body part comprising the tissue to be treated, with a movement device for moving the plasma source relative to the surface of the tissue, and with a control device for controlling the movement device and for controlling the operation of the plasma source, wherein the control device has means for adjusting the plasma output as a function of the position relative to the tissue. The invention solves the technical problem of permitting more reliable and faster plasma treatment of living tissue.