Disclosed are compositions and methods related to cancer treatment via the modulation of autophagy. The disclosure provides agents that increase the rate of autophagy as well as agents that decrease the rate of autophagy with associated targets. Furthermore, the disclosure also provides methods for screening for an agent for treating cancer via modulation of the rate of autophagy.Linvention porte sur des compositions et sur des procédés qui concernent de nouvelles cibles pour le traitement du cancer par modulation de lautophagie.