The present invention relates to desferoxamine conjugates, derivatives andanalogues thereof. In particular, the present invention relates to desferoxamineconjugates, analogues and derivatives thereof, and methods for reducing levelsof metals, especially iron, in a mammal. Uses of the compounds according to theinvention are also provided. Compounds of the present invention may also be usedto treat iron dyshomeostasis disorders, cancer, malaria and fungal infections.The compounds of the invention may be formulated into a pharmaceutical compositionor packaged into kits.