NEMETH, Jennifer F.,NISHIOKA, JR.,HEIDRICH, Bradley J.,DINH, Thai,CARDOSO, Rosa Maria Fernandes,PIZUTTI, Darlene,STRAKE, Brandy,FISHER, Jamie,ATTAR, Ricardo Marcos,GAUDET, Francois,SALVATI, Mark E.
申请号：
SG11201803675R
公开号：
SG11201803675RA
申请日:
2016.11.01
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
Provided herein are antibodies that specifically bind to IL1RAP. Also described are related polynucleotides capable of encoding the provided IL1RAP-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor IL1RAP-expressing cancer progression, regression, or stability； to determine whether or not a patient should be treated for cancer； or to determine whether or not a subject is afflicted with IL1RAP-expressing cancer and thus may be amenable to treatment with an IL1RAP-specific anti-cancer therapeutic, such as the multispecific antibodies against IL1RAP and CD3 described herein.
