PROBLEM TO BE SOLVED: To provide agents, and foods and drinks having osteoclast differentiation inhibitory action and osteoblast differentiation promoting action, and useful for osteoporosis.SOLUTION: To provide an osteoclast differentiation inhibitor, a bone formation promoter, and an osteoporosis preventing or improving agent, comprising toddaculin as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】破骨細胞分化抑制作用、骨芽細胞分化促進作用を有し、骨粗鬆症に有用な薬剤や飲食物の提供。【解決手段】トダクリン(toddaculin)を有効成分として含有する、破骨細胞分化抑制剤、骨形成促進剤、骨粗鬆症の予防または改善剤。【選択図】なし