The present invention provides a novel thiazole derivative useful as a VAP-1 inhibitor, a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like.A compound represented by the formula (I):R l -NH-X-Y-Z (I)wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.本發明提供一種有用於作為血管黏附蛋白質-1(vascular adhesion proteih-1,VAP-1)抑制劑、VAP-1相關疾病之預防或治療用醫藥劑等之新穎之噻唑(thiazole)衍生物。一種由式(I)所示之化合物或其醫藥上可接受之鹽:R 1 -NH-X-Y-Z (I)式中,每個符號係如本案說明書中定義。
