FRIEDRICH SCHEIFLINGER,PETER TURECEK,JUERGEN SIEKMANN
申请号：
IN4610/DELNP/2007
公开号：
IN260609B
申请日:
2007.06.15
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to a proteinaceous construe (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex said proteinaceous construe and at least one factor VIII (FVin) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
