An aqueous immunogenic composition which, after administration to a subject, is able to induce an immune response that is bactericidal against serogroups B, C, W135 and Y of N. meningitidis, the composition comprising: (i) a saccharide antigen capsular serogroup C conjugate (Ii) a capsular saccharide antigen from serogroup W135 conjugate (Iii) a capsular saccharide antigen from serogroup Y conjugate and (iv) a protein "NadA" in oligomeric form, a protein "741," a protein "936," a protein "953" and a protein 287, wherein: NadA has an amino acid sequence: (a) has 50% or more identity with SEQ ID NO: 2 and / or (b) comprises a fragment of at least 7 consecutive amino acids of SEQ ID NO: 1 and comprising an epitope of SEQ ID NO: 1 741 has an amino acid sequence which: (a) has 50% or more identity with SEQ ID NO: 3 and / or (b) comprises a fragment of at least 7 consecutive amino acids of SEQ ID NO: 3 and comprising an epitope of SEQ ID NO: 3 936 has an amino acid sequence which: (a) has 50% or more identity with SEQ ID NO: 4 and / or (b) comprises a fragment of at least 7 consecutive amino acids of SEQ ID NO: 4 and comprising an epitope of SEQ ID NO: 4 953 has an amino acid sequence which: (a) has 50% or more identity with SEQ ID NO: 5 and / or (b) comprises a fragment of at least 7 consecutive amino acids of SEQ ID NO: 5 and comprising an epitope of SEQ ID NO: 5 287 has an amino acid sequence which: (a) has 50% or more identity with SEQ ID NO: 6 and / or (b) comprises a fragment of at least 7 consecutive amino acids of SEQ ID NO: 6 and comprising an epitope from SEQ ID NO: 6 and one or more antigens capsular saccharides from serogroup C, W135 and Y are O-acetylated.Una composición inmunogénica acuosa que, después de su administración a un sujeto, es capaz de inducir una respuesta inmune que es bactericida frente a los serogrupos B, C, W135 y Y de N. meningitidis, comprendiendo la composición: (i) un antígeno sacárido capsular del serogrupo C conjugado (ii) un antígeno
