The present invention is directed to the provision of an ophthalmic composition suitable for intravitreal injection. The composition includes an amount of complexing agent that reacts with one or more endogenous components (e.g., hyaluronic acid) in the eye to form a mass of enhanced viscosity. This mass can aid in creating a desirable release profile of therapeutic agent本發明係有關於提供一適於玻璃體內注射之眼用組成物。此組成物含有一含量之錯合劑,其與眼部內之一或多種內生性組份(例如,玻尿酸)反應形成一具增強黏度之物料。此物料可助於產生一合意之治療劑釋放概況。