PROBLEM TO BE SOLVED: To provide a compound used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative disease (e.g. Alzheimer disease).SOLUTION: The present invention provides a compound represented by formula (I) or an optically active isomer thereof, or pharmaceutically acceptable salt thereof. In the formula, Rrepresents a hydrogen atom or an alkyl； Rrepresents an alkyl or a cycloalkyl； Rrepresents a halogen atom or a cyano； q represents an integer of 0 to 3； Z represents a nitrogen atom, C-H, or C-R； Rrepresents a cyano； Rrepresents a part of carbon ring； Rrepresents a substituted alkyloxy； and p represents an integer of 0 to 3.【課題】神経変性疾患（例えばアルツハイマー病）等のタウプロテインキナーゼ１の異常昂進に起因する疾患の予防及び／又は治療のために用いられる化合物の提供。【解決手段】式（I）で表される化合物もしくはその光学活性異性体、又はそれらの医薬上許容される塩。〔Ｒ2はＨ、アルキル等；Ｒ3はアルキル、シクロアルキル等；Ｒ20はハロゲン原子、シアノ等；ｑは０～３の整数；ＺはＮ、Ｃ－Ｈ又Ｃ－Ｒ２０；Ｒ4はシアノ等；Ｒ5は炭素環の一部等を表し；Ｒ6は置換アルキルオキシ等を表し；ｐは０～３の整数〕【選択図】なし
