Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to ameliorate symptoms of acute or chronic pancreatitis or to reduce the chance or severity of pancreatitis in an individual at risk of the condition. In other embodiments, disclosed herein are compositions and methods related to the amelioration of viral diseases through the pharmaceutical manipulation of calcium signaling. In further embodiments, disclosed herein are compositions and methods related to the amelioration of Th17-induced diseases through the pharmaceutical manipulation of calcium signaling.本發明揭示經由鈣信號傳導之藥物操縱以改善胰腺炎相關之組合物及方法。該等組合物及方法可用於改善急性或慢性胰腺炎之症狀，或降低處於該病狀之風險下的個體中胰腺炎的機率或嚴重程度。在其他實施例中，本文揭示經由該鈣信號傳導之藥物操縱以改善病毒性疾病相關之組合物及方法。在其他實施例中，本文揭示經由該鈣信號傳導之藥物操縱以改善經Th17誘導之疾病相關之組合物及方法。
