Roger A. Rajewski,Mehmet Tanol,Ingrid Gunda Georg,Michelle P. McIntosh
申请号：
US12538619
公开号：
US08318787B2
申请日:
2009.08.10
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A prodrug that has a prodrug moiety that degrades into a compound having the general Formula I with R3 being an alcoholic moiety can be useful in therapies for neurodegenerative diseases as well as cancer. Accordingly, the prodrug compounds can have a structure of Formula I, analogs thereof, derivatives thereof, or salts thereof, wherein: A and B are sulfur or oxygen R1 and R2, in para, meta, or ortho position, are independently halogen, alkyl, alkoxy, haloalkyl, where R1 and R2 independently are straight chain, branched, substituted or unsubstituted and R3 is a prodrug moiety. As examples, the prodrug can have a structure of any of Formulas I-V, which as shown in the specification.
