The present investigation discloses a simple, economical and a novel apparatus and method to determine the duration of bioadhesion of bioadhesive solid dosage form In vitro. Drug action at the site is dependent upon its residence time or the duration of bioadhesion of dosage form or pellets at the particular site. The apparatus was design and optimized by changing the diameter of glass tube, pellets and height of overflow rube and flow rate to record the duration of bioadhesion in vitro closer to the in vivo conditions. Conditions were simulated by using the mucous membrane of the site where the dosage forms are intended to adhere and the corresponding physiological solution.
