BLUMBERG, RICHARD,BAKER, KRISTI,PYZIK, MICHAL,GANDHI, AMIT
申请号：
CA2983794
公开号：
CA2983794A1
申请日:
2015.04.21
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.
