Jeffery C. FAIRMAN,Jon H. HEINRICHS,Wei CHAN,Olivier Jean Gérard MARCQ,Christopher R. Behrens
申请号：
US16459303
公开号：
US20200054739A1
申请日:
2019.07.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods for the production of immunogenic compositions containing a non-natural amino acid are disclosed. The non-natural amino acid can be a site for attachment of antigens, such as bacterial capsular polysaccharides, to make immunogenic conjugates. Bio-orthogonal attachment chemistry incorporated into the non-natural amino acids allows for more efficient and potent antigen presentation to the immune system, simplified purification, and more well-defined structure of these semi-synthetic immunogens.
