A method of generating a 3D x-ray image cube movie from 2D x-ray images of a patient is provided. The method includes converting first multiple sets of x-ray images of a lung captured at different projection angles into second multiple sets of x-ray images of the lung corresponding to different breathing phases. The method further includes generating a static image cube from each set of the second multiple sets of x-ray images at a respective breathing phase using back projection. The method includes combining the static image cubes corresponding to the different breathing phases of the lung into a 3D x-ray image cube movie through temporal interpolation.
