Large formula cycles (1) as pde1 inhibitors and their use as drugs are currently available, especially for the treatment of neurodegenerative disorders and psychosis. Claim 1: a compound calculated according to formula (1),Ring a is a heteroaromatic ring with 5 to 6 members, ring a is phenyl, ring B is a heteroaromatic ring with 5 to 6 members, ring B is phenyl, ring a is a link between 5 and W, ring a is a heteroaromatic ring of 5 to 6 members, then ring a is C, ring is n, or =Z = C； when ring a is 6-member or phenyl heteroaromatic ring, y = z = C； when ring B is a heteroaromatic ring with 5 members, one V and W is C, the other is n, or V = w = C； when ring B is a heteroaromatic ring with 6 members or phenyl, then v = w = C； when ring B is a heteroaromatic ring with 6 members or phenyl, then y = z = C； when ring B is a heteroaromatic ring with 6 members or phenyl, then y = z = C； when ring B is a heteroaromatic ring with 6 members or phenyl, then y =；a. Embedding is a saturated chain composed of 5-7 members, consisting of carbon atoms and one or more oxygen atoms substituted. The condition is that the chain does not contain O-O links, provided that v-links cannot be o-n links, and a links cannot be o-n links； R1 is saturated from hydrogen, c83218c83318383248 and cyclopentadiene allyl compound c838331838383248 from hydrogen, c832118c83318383248, in which c8332183318324 and cyclopentadiene-c832312483248332483248324248b can be replaced by one or more halogens；R2. Selected from c83321218833326a, cycloquilo c832318331832626, saturated single cycle, oxetanil, tetrahydrofuran and tetrahydropyridinol, each substance can be replaced by one or more halogens, or one of its drug acceptable salts；La presente proporciona macrociclos de fórmula (1) como inhibidores de PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), en el que: el anillo A
