594556 Disclosed herein are carboxamide compounds, pharmaceutical compositions comprising said compounds and the use of said compounds in the treatment of metabolism-related disorders and conditions, such as those mediated by activating the AMPK pathway in a cell. Embodiments of the compounds include the following: 5-(4-(4-cyanobenzyl)piperazine-1-carbonyl)-N-(1-(4-cyanobenzyl)piperidin-4-yl)picolinamide, and (S)-5-(4-(4-chlorophenyl)piperazine-1-carbonyl)-N-(1-(4-fluorobenzyl)pyrrolidin-3-yl)picolinamide.
