The present disclosure includes methods and compositions for the treatment orprevention of diseases and disorders characterized by excessive ormisregulated cellular proliferations, including methods for the treatment oftumors. The methods involve the use of pharmaceutical compositions comprisingat least one agent selected from the group consisting of a LIF preparation, aBMP preparation, a BMPR signalling activator, and a LIFR signalling activator.The disclosure also includes LIF preparations, BMP preparations, BMPRsignalling activator, and LIFR signalling activators, and methods for theidentification of LIF preparations, BMP preparations, BMPR signallingactivator, and LIFR signalling activators. The disclosure also includespharmaceutical compositions comprising at least one agent selected from thegroup consisting of a LIF preparation, a BMP preparation, a BMPR signallingactivator, and a LIFR signalling activator.
