VACHON, MICHAEL,AWADESH, MISHRA K.,SNOW, ROBERT A.,GUIVARC'H, POL-HENRI
申请号：
CA2484375
公开号：
CA2484375C
申请日:
2003.05.02
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Disclosed is a pharmaceutically acceptable oral dosage form comprisingfenofibrate, phospholipid, a buffer salt, a water-soluble bulking agentselected from maltodextrin, mannitol, and combinations thereof, a cellulosicadditive, beads or crystals of a pharmaceutically acceptable water-solubleexcipient support material, a polyvinylpyrrolidone or crospovidone,croscarmellose sodium, granular mannitol, sodium dodecyl sulfate, silicondioxide, and a stearate, wherein the fenofibrate is in the form ofmicroparticles, and wherein at least a portion of the phospholipid is coatedon the surfaces of the fenofibrate microparticles, the phospholipid coatedmicroparticles are embedded in a matrix comprising the water-soluble bulkingagent, phospholipid that is not coated on the microparticles, the buffer saltand the cellulosic additive, and the matrix is coated on up to 100% of thesurfaces of the beads or crystals of the excipient support material.
