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COMPOSITION PHARMACEUTIQUE LIQUIDE
专利权人:
ARES TRADING S.A.
发明人:
RINALDI, GIANLUCA,FRATARCANGELI, SILVIA,DEL RIO, ALESSANDRA
申请号:
CA2948746
公开号:
CA2948746A1
申请日:
2015.05.15
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, a citrate buffering agent/system such as sodium citrate/citric acid, and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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