Provided is an air-cushion block structure, and a mattress including the air-cushion block structure installed therein. The mattress of the present invention is provided with an air-cushion block structure which includes: an upper cushion having a first core hole vertically formed therein; and a lower cushion which has a second core hole vertically formed therein, and is disposed at a lower portion of the upper cushion. Accordingly, it is possible to stably transfer a weight of a user applied from an upper portion of the air-cushion block structure to a lower portion thereof, as well as, achieve a structure that stably supports the weight of the user by minimizing an occurrence of torsional deflection caused by the weight.