Byoung Se Kwon,Kwang-Hui Kim,Young-Ho Kim,Ho-sik Oh,Don-Gil Lee,Seung-Joo Lee,Beom-Kyu Choi,Insoo Park,Chungyong Han
申请号：
US16358636
公开号：
US20190375851A1
申请日:
2019.03.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided is a monoclonal antibody which specifically recognizes B cell lymphoma cells and a use thereof. More specifically, provided are the monoclonal antibody； a pharmaceutical composition for preventing or treating B cell lymphoma including the monoclonal antibody； a composition for diagnosing B cell lymphoma including the monoclonal antibody； a method for providing information for diagnosing B cell lymphoma using the monoclonal antibody； a chimeric antigen receptor (CAR) protein including i) the antibody, ii) a transmembrane domain, and iii) an intracellular signaling domain； a recombinant vector which expresses the CAR protein； a CAR-modified T cell transformed with the recombinant vector； a pharmaceutical composition for preventing or treating B cell lymphoma including the CAR-modified T cell； and an antibody-drug conjugate wherein the monoclonal antibody and a drug are conjugated.
