25 101 73 71 3 1 53 6 1112131 32 32 3215a15b141 32 32 3 216a16b1 4 2 31 41 416a16b1 4125 101 73 71 31 53 62122231 3 2 32 31225a25b241 32 32 31226a26b1 42 31 41 426a26b1 469231 12 3 20 5 207233 12N2N21 46 7 9 6792021a21L11bAA1 4zA compound with the formula (I) and salts and solvates thereof wherein: when there is a double bond present between C2 and C3 R is selected from the group consisting of: (ia) C aryl group optionally substituted by one or more substituents selected from the group comprising: halo nitro cyano ether C alkyl C heterocyclyl and bis oxy Calkylene (ib) C saturated aliphatic alkyl (ic) Csaturated cycloalkyl (id) (Formula (S)) wherein each of R R and R are independently selected from H C saturated alkyl C alkenyl C alkynyl and cyclopropyl where the total number of carbon atoms in the R group is no more than 5 (ie) (Formula (T)) wherein one of R and R is H and the other is selected from: phenyl which phenyl is optionally substituted by a group selected from halo methyl methoxy pyridyl and thiophenyl and (if) (Formula (U)) where R is selected from: H C saturated alkyl C alkenyl Calkynyl cyclopropyl phenyl which phenyl is optionally substituted by a group selected from halo methyl methoxy pyridyl and thiophenyl when there is a single bond present between C2 and C3 R is (Formula (V)) where R and R are independently selected from H F Csaturated alkyl C alkenyl which alkyl and alkenyl groups are optionally substituted by a group selected from C alkyl amido and C alkyl ester or when one of R and R is H the other is selected from nitrile and a C alkyl ester when there is a double bond present between C2 and C3 R is selected from the group consisting of: (ia) C aryl group optionally substituted by one or more substituents selected from the group comprising: halo nitro cyano ether carboxy ester C alkyl C heterocyclyl and bis oxy C alkylene (ib) C saturated aliphatic alkyl (ic) C saturated cycloalkyl (id) (Formula (W)) wherein each of R R and R are independentl
