Disclosed is the use of a compound of formula I wherein X is O, S, SO or SO2； R1 is halogen, trihalomethyl, -OH, C1-7alkyl, C1-4alkoxy, trifluoromethoxy, phenoxy, cyclohexylmethyloxy, pyridylmethoxy, cinnamyloxy, naphthylmethoxy, phenoxymethyl, -CH2-OH, -CH2-CH2-OH, C1-4alkylthio, C1-4alkyl-sulfinyl, C1-4alkylsulfonyl, benzylthio, acetyl, nitro or cyano, or phenyl, phenylC1-4alkyl or phenyl-C1-4alkoxy each phenyl group thereof being optionally substituted by halogen, CF3, C1-4alkyl or C1-4alkoxy； R2 is H, halogen, trihalomethyl, C1-4alkoxy, C1-7alkyl, phenethyl or benzyloxy； R3H, halogen, CF3, OH, C1-7alkyl, C1-4alkoxy, benzyloxy, phenyl or C1-4alkoxymethyl； each of R4 and R5, independently is H or a residue of formula (a) wherein each of R8 and R9, independently, is H or C1-4alkyl optionally substituted by halogen； and n is an integer from 1 to 4； or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof； or a compound of formula II wherein R1a is halogen, trihalomethyl, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4alkylsulifinyl, C1-4alkylsulfonyl, aralkyl, optionally substituted phenoxy or aralkyloxy； R2a is H, halogen, trihalomethyl, C1-4alkyl, C1-4alkoxy, aralkyl or aralkyloxy； R3a is H, halogen, CF3, C1-4alkyl, C1-4alkoxy, C1-4alkylthio or benzyloxy； R4a is H, C1-4alkyl, phenyl, optionally substituted benzyl or benzoyl, or lower aliphatic C1-5acyl； R5a is H, monohalomethyl, C1-4alkyl, C1-4alkoxy-methyl, C1-4alkyl-thiomethyl, hydroxyethyl, hydroxypropyl, phenyl, aralkyl, C2-4alkenyl or -alkynyl； R6a is H or C1-4alkyl； R7a is H, C1-4alkyl or a residue of formula (a) as defined above, Xa is O, S, SO or SO2； and na is an integer of 1 to 4； or a pharmaceutically acceptable salt, hydrate, solvate, isomer or prodrug thereof； in the manufacture of a medicament for the treatment or prophylaxis of scLE and related autoimmune cutaneous conditions.ｓｃＬＥおよび関連する自己免疫疾患皮膚症状の処置または予防用医薬の製造における式Ｉ：〔式中、ＸはＯ、Ｓ、ＳＯまたはＳＯ２であり；Ｒ１はハロゲン、トリハロメチル、－ＯＨ、Ｃ１－７アルキル、Ｃ１－４アルコキシ、ト
