organic peptide system, luminescent compound and derivative of peryl alcohol, method of preparation of the system and use in drug transport and photodynamic therapy
ANTÔNIO CARLOS CHAVES RIBEIRO,GEOVANY ALBINO DE SOUZA,TATIANA DUQUE MARTINS
申请号：
BR102018070770
公开号：
BR102018070770A2
申请日:
2018.10.09
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
organic peptide system, luminescent compound and derivative of peryl alcohol, method of preparation of the system and use in drug transport and photodynamic therapy. the present invention is an organic system consisting of self-organized structures of diphenylalanine peptide, containing a fluorophore as an additive, preferably coumarin-6, and containing adhered in its mass organic chemical compound with interest in the treatment of various cancers, preferably, peryl alcohol. the system thus constituted has the capacity, when absorbing uv / vis light, including the region of the therapeutic window, to convert fundamental oxygen into singlet oxygen, which is the compound that promotes changes in cancer cells that lead to their destruction and that characterize the photodynamic therapy and that also promotes various oxidative processes. also, the system can be used for the targeted delivery of the drug peryl alcohol, since it is contained in the peptide structure when in the form of vesicles and that, due to the ability of peptides to self-organize in different structures depending on the production medium and / or administration, if converted into different structures, is released in half. in addition to vesicles, other self-organized peptide structures can also be obtained, in the present invention, a gel, which is formed in the presence of the therapeutic compound, with potential for application on surfaces for topical use or on electrodes.sistema orgânico de peptídeo, composto luminescente e derivado de álcool perílico , método de preparação do sistema e uso em carreamento de fármaco e terapia fotodinâmica. a presente invenção trata-se de um sistema orgânico constituído de estruturas auto-organizadas de peptídeo difenilalanina, contendo um fluoróforo como aditivo, preferencialmente cumarina-6, e contendo aderidas em sua massa composto químico orgânico com interesse no tratamento de cânceres diversos, preferencialmente, o álcool períli
