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Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same
专利权人:
发明人:
Mark Schoenfisch,Daniel Riccio,Julia Nugent,Nathan Stasko
申请号:
US13975930
公开号:
US09713652B2
申请日:
2013.08.26
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.
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