The present invention relates to an anti-inflammatory composition comprising 14-3-3 sigma gene and/or protein as an active ingredient. The 14-3-3 sigma gene is preferred to be composed of a base sequence of SEQ ID NO.1; and provided in the present invent is an anti-inflammatory composition comprising a 14-3-3 sigma protein as an active ingredient. In an embodiment of the present invention, the 14-3-3 sigma protein is preferred to be composed of a base sequence of SEQ ID NO. 2, but is not limited to the same; and provided in the present invention is an expression vector controlling inflammatory cytokine comprising the 14-3-3 sigma gene composed of SEQ ID NO.1 as an active ingredient.본 발명은 14-3-3 시그마 유전자 및/또는 단백질을 유효성분으로 포함하는 항염증용 조성물에 관한 것이다.