It is a kind of to treat acute myelogenous leukemia, acute lymphoblastic leukemia, high-risk myelodysplastic syndrome, and/or HR-MDS/AML mammals apply a kind of compound comprising amorphous solid dispersion Thienotriazolodiazepcompounds formula, wherein R1 is that alkyl (1) to have carbon number be 1-4, R2 be hydrogen atom Halogen atom Or with the alkyl that carbon atom number is 1-4 optionally by halogen atom or hydroxyl, R3 is halogen atom Phenyl optionally has 1-4 carbon atom by halogen atom, alkyl, the alkoxy or cyano for being 1-4 with carbon number - NR 5-(CH 2) m R6, wherein R5 is hydrogen atom or the alkyl with carbon number for 1-4, and m is the integer of 0-4, and R6 is phenyl or pyridyl group optionally by halogen atom.
