SUN, TIANXIAO,LEVESQUE, PHILIP, M.,BROWN, ALICJA, T.,LEE, CYNTHIA, K.
申请号：
EP10804910
公开号：
EP2461679A4
申请日:
2010.07.23
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: wherein R1, R2, and R3 may be identical or different and each is a straight or branched lower alkyl group having from 1 to 4 carbon atoms； an inorganic salt； glutamic acid or a salt thereof； a polyol； a physiologically acceptable buffer, and a pharmaceutically acceptable carrier. The tertiary amine N-oxide may be trimethylamine-N-oxide, (CH3)3NO. The formulation is useful for vaccine stabilization.
