Calzone, Frank J.,Deshpande, Rajendra V.,Tsai, Mei-Mei
申请号:
AU2010257339
公开号:
AU2010257339B2
申请日:
2010.12.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
#$%^&*AU2010257339B220121108.pdf#####ABSTRACT The present invention provides compositions and methods relating to or derived from anti-IGF-IR antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-lR antibodies that bind human IGF-lR, IGF-IR-binding fragments and derivatives of such antibodies, and IGF-IR5 binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having IGF- I R-related disorders or conditions.