Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
Ferretti, Antonio Christian,Man, Hon-Wah,Muslehiddinoglu, Jale,Xu, Jean,Yong, Kelvin Hin-yeong,Beauchamps, Marie Georges,Kothare, Mohit Atul,Zhou, Nanfei,Boersen, Nathan Andrew,Li, Ying,Hilgraf, Rober
申请号：
AU2015211036
公开号：
AU2015211036A1
申请日:
2015.01.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3- hydroxy-4-methy1cydohexylamino)-pyrimidine-5-carboxamide (Compound I). In another aspect, provided herein are methods for preparing certain compounds, including Compound I as described herein, as well as intermediates useful in such methods. In certain aspects, the solid forms of Compound I are useful for inhibiting a kinase in a cell expressing said kinase, for example JNK1 or JNK2. In another aspect, the solid forms of Compound I are useful for treating or preventing one or more disorders selected from interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, or lupus.
