PROBLEM TO BE SOLVED: To provide a medicament containing a receptor agonist useful for treating emphysema and other diseases associated with pulmonary alveolar damage.SOLUTION: A retinoic acid receptor (RAR) agonist, especially an RAR&gamma receptor-selective agonist which is selective to an RAR&gamma receptor and has a selectivity of the RAR&gamma receptor at least 20 times compared with RAR&alpha and RAR&beta receptors, is effective for treating emphysema and other diseases associated with pulmonary alveolar damage. The medicament contains one or more kinds of the above agonist. As the agonist, a compound represented by formula VII is especially excellent.COPYRIGHT: (C)2008,JPO&INPIT【課題】気腫または他の肺胞損傷に関連する疾患の治療に有用な受容体作動薬を含有する医薬の提供。【解決手段】レチノイン酸受容体(BAR)作動薬、特にBARγ受容体に選択的であり、BARαおよびBARβ受容体と対比して、少なくとも20倍であるBARγ選択的作動薬が、気腫または他の肺胞損傷に関連する疾患の治療に有効であり、1種類またはそれ以上の該作動薬を含有する医薬。該作動薬としては、特に下記化合物が優れる。【選択図】なし
