The invention provides novel selective estrogen receptor modulator compounds of the general formula:wherein R1 and R2, which are the same or different area) H, halogen, OCH3, OH； orwhere X is O, NH or S； and n is an integer from 1 to 4； and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, -CH2C=CH or -CH2CH2OH； or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring； orc) -Y-(CH2)nCH2-O-R6where Y is O, NH or S and n is an integer from 1 to 4； and R6 is H, -CH2CH2OH, or -CH2CH2Cl； ord) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy； andR3 is H, halogen, OH or -OCH3；stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties.
