Provided is a treating or preventing agent for the eye disease caused by eye angiogenesis, which contains a morpholin compound represented by formula (1) or its salt as active ingredient. [wherein, ring A represents an optionally substituted aryl etc.； ring B represents an optionally substituted arylene etc.； m=0~2； n=1~5； X represents a bond etc.； Y represents a bond etc.； Z represents a hydrogen etc.].本發明係提供以通式(1)表示之嗎啉化合物或其醫藥上容許之鹽為有效成分，作為起因於眼血管新生之眼科疾病之治療劑或預防劑。□[式中，環A表示可具有取代基之芳基等；環B表示可具有取代基之伸芳基等；m=0至2；n=1至5；X表示鍵結等；Y表示鍵結等；Z表示氫原子等。]
