abstract the invention relates to novel rauwolfia alkaloid derivatives of formula (i) (i) combinations of rauwolfia alkaloid derivatives and mitochondrial inhibitor, eg metformin, and the use of rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (i). Patent Combination Therapy for the Treatment of Cancer and Immunosuppression (i) The invention relates to novel rauwolfia alkaloid derivatives of formula (i), combinations of rauwolfia alkaloid derivatives and a mitochondrial inhibitor, for example metformin, and the use of rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and to achieve clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell to the compound of formula (I).abstract the invention relates to novel rauwolfia alkaloid derivatives of formula (i) (i) combinations of rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. the invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (i). ____________________________________________________________________________________________ resumo patente de invenção: "terapia de combinação para o tratamento de câncer e imunossupressão" (i) a invenção diz respeito a novos derivados de alcalóides de rauwolfia de fórmula (i), combinações de derivados de alcalóides de rauwolfia e um inibidor mitocondrial, por exemplo metformina, e a utilização de derivados de alcalóides de rauwolfia em combinação com inibidor mitoco
