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具光學活性的二氫吡啶膦酸酯之製造方法
专利权人:
NISSAN CHEMICAL INDUSTRIES; LTD.
发明人:
TAKADA, YASUTAKA,高田泰孝,高田泰孝,MATSUMOTO, HIROO,松本浩郎,松本浩郎
申请号:
TW093128737
公开号:
TWI361801B
申请日:
2004.09.22
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
This Hair Ming Department provide make the anti-high blood Pressure Drug, Narrow heart diseases of As control Treatment Drug it is useful according to Fu Horizons, (the You Xiao Shuai System of efonidipine) Guang Learn active matters make method. The racemate dissolution molten Elixirs Tone System of what of compound shown in Will formulas (1) are at Over Eat and solution, Shu Over Eat and solution are added either one Guang Learn Huo Wu Knot crystalline substance of compound shown in above-mentioned formula (1) and make As Jing Seed Shang what, it is brilliant that the above-mentioned light Learn that crystalline substance Seed is added property object Knot living are precipitated, again, the surplus mixtures existed of either one Guang Learn active matters Over of compound shown in the above-mentioned formulas of Will (1) dissolve what Rong Elixirs Tone System Cheng Over Eat and solution, surplus there are sides Guang Learn Huo Wu Knot crystalline substances to make As Jing Seed by Shu Over Eat and solution Jia Ru Over Shang what, surplus there are compound Guang Learn active matters System shown in the formula (1) of sides Guang Learn Huo Wu Knot crystalline substance As characteristics to make method by Shu Over in precipitation.本發明係提供作為抗高血壓藥、狹心症治療藥有用之依褔地平(efonidipine)之光學活性物之有效率的製造方法。將式(1)所示化合物之外消旋物溶解於溶劑調製成過飽和溶液,於上述過飽和溶液加入上述式(1)所示化合物任一方之光學活性物結晶作為晶種,析出上述所加入晶種之光學活性物結晶,又,將上述式(1)所示化合物任一方之光學活性物之過剩存在之混合物溶解於溶劑調製成過飽和溶液,於上述過飽和溶液加入過剩存在一方之光學活性物結晶作為晶種,析出上述過剩存在一方之光學活性物結晶為特徵之式(1)所示化合物之光學活性物之製造方法。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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