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(氮雜)中氮茚衍生物及其藥物用途
专利权人:
KISSEI PHARMACEUTICAL CO. LTD.
发明人:
MASATO IIZUKA,KAZUO SHIMIZU
申请号:
HK14100528.5
公开号:
HK1188442B
申请日:
2014.01.17
申请国别(地区):
HK
年份:
2016
代理人:
摘要:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. The present invention relates to (aza)indolizine derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In the formula, 0 to 2 of X 1 , X 2 , X 3 and X 4 are a nitrogen atom and the others are CR 1 ; one of T 1 and T 2 represents cyano and the other represents a group represented by the following formula (A), with the proviso that when T 1 is cyano, at least one of X 1 to X 4 is a nitrogen atom; R 1 independently represents a hydrogen atom, a halogen atom, a hydroxy group, C 1-6 alkyl, C 1-6 alkoxy or the like; ring U represents a benzene ring or the like; m represents integral number from 0 to 2; R 2 independently represents a fluorine atom, a hydroxy group or the like.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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