Oregon Health & Science University;Sanofi Pasteur, Inc.
发明人:
Ross, Ted Milburn,Alefantis, Tim,Carter Jr., Donald Martin,Darby, Christopher Austin,Kleanthous, Harold
申请号：
AU2015364253
公开号：
AU2015364253A1
申请日:
2015.12.18
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
