THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
Nicholas COX,Jennifer R. COCHRAN,Mark SMITH,James R. KINTZING
申请号：
US15458852
公开号：
US20170304342A1
申请日:
2017.03.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the knottin-drug conjugates, as well as methods of using the knottin-drug conjugates, e.g., for therapeutic purposes.
