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PHOTO-CONTROLLED REMOVAL OF TARGETS IN VITRO AND IN VIVO
专利权人:
THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERV
发明人:
Hisataka Kobayashi,Peter Choyke,Martin John Schnermann
申请号:
US15318104
公开号:
US20170122853A1
申请日:
2015.08.07
申请国别(地区):
US
年份:
2017
代理人:
摘要:
This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from a hydrophilic molecule, to one that is hydrophobic, resulting in aggregation of IR700 and anything bound to it. For example, the disclosed IR700-molecule conjugates and methods provide photo-controlled ways to control the pharmacokinetics of a drug in vivo, and can be used to remove undesired agents from environmental or food samples or to isolate target molecules in a laboratory.
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