DEWDNEY, NOLAN JAMES,KENNEDY-SMITH, JOSHUA,LOE, BRADLEY E.,LOU, YAN,MCINTOSH, JOEL,OWENS, TIMOTHY D.,SOTH, MICHAEL,SWEENEY, ZACHARY KEVIN,TAYGERLY, JOSHUA PAUL GERGELY,KONDRU, RAMA K.
申请号：
DK09709135
公开号：
DK2242749T3
申请日:
2009.01.27
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one deriva-tives according to generic Formulae I-III : wherein, variables R, X, Y1, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat in-flammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
