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STABLE BENZIMIDAZOLE FORMULATION
专利权人:
ERICA LAHAV;RAFFAEL LAHAV;VALERIE AZOULAY
发明人:
RAFFAEL LAHAV,ERICA LAHAV,VALERIE AZOULAY
申请号:
US13456411
公开号:
US20120244219A1
申请日:
2012.04.26
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A stable composition with a benzimidazole derivative, such as Omeprazole, which does not contain a separating layer between the active compound and an enteric coating layer. Instead, the enteric coating layer is applied as a solution with a pH value of at least 6.5, and more preferably in a range of from about 7 to about 10, directly to the benzimidazole derivative substrate. This solution, with the optional addition of a plasticizer, can be directly coated onto the substrate without any necessity for an intermediate layer. Furthermore, in this pH range, the enteric coating is optionally applicable in an aqueous solution, thereby obviating the need for organic solvents for dissolving the enteric coating material. The resultant formulation maintains the stability of the benzimidazole derivative during storage and at the same time protects the product during passage through the acidic environment of the stomach.
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